NNC45-0781
NNC45-0781 Basic information
- Product Name:
- NNC45-0781
- Synonyms:
-
- NNC45-0781
- 2H-1-Benzopyran-7-ol, 3,4-dihydro-3-phenyl-4-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-, (3S,4R)-
- NNC45 0781,NNC-45-0781,NNC450781
- CAS:
- 207277-66-5
- MF:
- C27H29NO3
- MW:
- 415.52
- Mol File:
- 207277-66-5.mol
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NNC45-0781 Chemical Properties
- Boiling point:
- 563.7±50.0 °C(Predicted)
- Density
- 1.185±0.06 g/cm3(Predicted)
- pka
- 9.87±0.60(Predicted)
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NNC45-0781 Usage And Synthesis
Uses
NNC45-0781 is a tissue-selective estrogen partial-agonist.
in vivo
NNC45-0781 (NNC 45-0781) shows that it is a very promising tissue-selective estrogen agonist. Total serum cholesterol is significantly increased in the vehicle-treated group as compared to the sham animals. All of the animals receiving NNC45-0781 at doses of 10 nmol/g or higher, has significantly lower levels of total serum cholesterol as compared to the vehicle treated group[1].
References
[1] Bury PS, et al. Synthesis and pharmacological evaluation of novel cis-3,4-diaryl-hydroxychromanes as high affinity partial agonists for the estrogen receptor. Bioorg Med Chem. 2002 Jan;10(1):125-45. DOI:10.1016/s0968-0896(01)00257-7
NNC45-0781Supplier
MedChemexpress LLC
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- 021-58955995
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 15801484223;
- psaitong@jm-bio.com
TargetMol Chemicals Inc.
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Biosynth Biological Technology (Suzhou) Co Ltd
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- 51288865780
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