Nolomirole hydrochloride Usage And Synthesis

Description

Nolomirole HCl is a Dopamine Receptor Agonist. Nolomirole is able to attenuate the heart failure signs in the monocrotaline-induced congestive heart failure.

Uses

Nolomirole (CHF 1035) hydrochloride is an orally active and selective DA2 dopaminergic receptor/α2-adrenoceptor agonist. Nolomirole attenuates the heart failure signs in the Monocrotaline (HY-N0750)-induced congestive heart failure model. Nolomirole increases cardiac output[1][2].

References

[1] Pasini E, et al. Effect of nolomirole on monocrotaline-induced heart failure. Pharmacol Res. 2004 Jan;49(1):1-5. DOI:10.1016/s1043-6618(03)00246-9
[2] Torp-Pedersen C, et al. A randomised trial of a pre-synaptic stimulator of DA2-dopaminergic and alpha2-adrenergic receptors on morbidity and mortality in patients with heart failure. Eur J Heart Fail. 2008 Jan;10(1):89-95. DOI:10.1016/j.ejheart.2007.10.012