CR665 (H-D-Phe-D-Phe-D-Nle-D-Arg-NH-4-Picolyl) Chemical Properties

Density 

1.26±0.1 g/cm3(Predicted)

pka

13.36±0.46(Predicted)

form 

Solid

color 

White to off-white

CR665 (H-D-Phe-D-Phe-D-Nle-D-Arg-NH-4-Picolyl) Usage And Synthesis

Uses

CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].

References

[1] Anne E Olesen, et al. A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone. Clin Pharmacokinet DOI:10.1007/s40262-012-0023-8
[2] Francis M Hughes Jr, et al. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. Open Med Chem J. 2013 Nov 4;7:16-22. DOI:10.2174/1874104501307010016