DBCO-PEG4-acid Chemical Properties

Boiling point:

839.7±65.0 °C(Predicted)

Density 

1.27±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DMF, DCM

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

DBCO-PEG4-acid Usage And Synthesis

Description

DBCO-NHCO-PEG4-acid is an analog of DBCO-Acid with a hydrophilic PEG spacer arm, which improves water solubility. This reagent is a non-activated building block with enhanced solubility in aqueous media and can thus be used to derivatize amine-containing molecule through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-PEG4-acid is a a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005