N-(Azido-PEG2)-N-bis(PEG4-t-butyl ester) Chemical Properties

storage temp. 

2-8°C, protect from light

form 

Viscous Liquid

color 

Colorless to light yellow

N-(Azido-PEG2)-N-bis(PEG4-t-butyl ester) Usage And Synthesis

Description

N-(Azido-PEG2)-N-bis(PEG4-t-butyl ester) is a branched PEG compound with a terminal azide group. The azide groups is very reactive with alkyne such as DBCO, BCN and propargyl reagnet via Click Chemistry. . The t-butyl protected carboxyl groups can be deprotected under mild acidic conditions.

Uses

N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-bis(PEG4-Boc) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005