5-(4-METHYLPHENYL)-2-FUROIC ACID Chemical Properties

Melting point:

179-181 °C (lit.)

Boiling point:

374.6±30.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Store at room temperature

pka

3.21±0.10(Predicted)

form 

solid

Appearance

Light yellow to yellow Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2932190090

MSDS

• Language:English Provider:SigmaAldrich

5-(4-METHYLPHENYL)-2-FUROIC ACID Usage And Synthesis

Synthesis

Step 3: Accurately weigh 310 mg (1.11 mmol) of the intermediate methyl 4-(4-methoxyphenyl)furan-2-carboxylate and add it slowly dropwise to a 5 mL methanol mixture containing 1 mL of 4 mol/L NaOH solution and heat to reflux for 3 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and concentrated to dryness under reduced pressure. The pH was adjusted to about 1 with 10% dilute hydrochloric acid and subsequently extracted three times with ethyl acetate. The organic phases were combined, washed twice with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 290 mg of the intermediate 5-(4-methoxyphenyl)furan-2-carboxylic acid in 100% yield.

References

[1] Patent: CN103992311, 2017, B. Location in patent: Paragraph 0103; 0137

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