5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE Chemical Properties

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: 10 mM

form 

Powder

color 

White to yellow

Water Solubility 

Soluble to 10 mM in water with gentle warming

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE Usage And Synthesis

Uses

ZD 7155 Hydrochloride, is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. it is shown to be more active than the prototype AT1 antagonist, losartan, and it’s orally active.

Biological Activity

A potent and selective competitive antagonist for the angiotensin II type 1 (AT 1 ) receptor. Displaces [ 125 I]-angiotensin II binding with an IC 50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT 1 antagonist, losartan.

storage

Desiccate at +4°C

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE(146709-78-6)Related Product Information

• ZD 7155
• ICI D7114
• 1-METHYL-1,2,3,4-TETRAHYDRO-[1,6]NAPHTHYRIDINE
• 4-PYRIDINAMINE, 5-ETHYL-2-METHYL-
• 2,6-DIMETHYL-PYRIDIN-4-YLAMINE
• 3,4-DIHYDRO-1,6-NAPHTHYRIDIN-2(1H)-ONE
• C-BIPHENYL-4-YL-METHYLAMINE HYDROCHLORIDE
• 1,2,3,4-TETRAHYDRO-1,6-NAPHTHYRIDINE
• Acetamide,N-(2-methyl-4-pyridinyl)-
• 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE