H-TYR-PRO-TRP-GLY-NH2 Chemical Properties

Boiling point:

1009.2±65.0 °C(Predicted)

Density 

1.380±0.06 g/cm3(Predicted)

storage temp. 

-15°C

pka

9.86±0.15(Predicted)

H-TYR-PRO-TRP-GLY-NH2 Usage And Synthesis

Uses

Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia[1][2][5].

in vivo

References

[1] Yang YR, et L. Opioid and antiopioid actions of Tyr-MIF-1, Tyr-W-MIF-1 and hemorphin-4 on rat locus coeruleus neurons: intracellular recording in vitro. Chin J Physiol. 1997 Sep 30;40(3):131-5. PMID:9434888
[2] Gergen KA, et al. Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Peptides. 1994;15(8):1505-11. DOI:10.1016/0196-9781(94)90130-9
[3] Gergen KA, et al. Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors. Eur J Pharmacol. 1996 Mar 18;298(3):235-9. DOI:10.1016/0014-2999(95)00823-3
[4] Harrison LM, et al. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther. 1998 Feb;284(2):611-7. PMID:9454805
[5] Erchegyi J, et al. Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1). Peptides. 1992 Jul-Aug;13(4):623-31. DOI:10.1016/0196-9781(92)90165-y

H-TYR-PRO-TRP-GLY-NH2(144450-13-5)Related Product Information

• hemorphin 7
• AETPTYPWRDAETGERC
• hemorphin 5
• ENDOMORPHIN-1
• VALORPHIN
• ENDOMORPHIN-1 (HUMAN, BOVINE) ACOH H2O
• LEU-VALORPHIN-ARG
• AC-GLY-ASP-TYR-SER-HIS-CYS-SER-PRO-LEU-ARG-TYR-TYR-PRO-TRP-TRP-LYS-CYS-THR-TYR-PRO-ASP-PRO-GLU-GLY-GLY-GLY-NH2, (DISULFIDE BOND) TRIFLUOROACETATE
• H-TYR-PRO-TRP-GLY-NH2