CALCIMYCIN A23187 HEMIMAGNESIUM SALT
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Basic information
- Product Name:
- CALCIMYCIN A23187 HEMIMAGNESIUM SALT
- Synonyms:
-
- CALCIMYCIN A23187 HEMIMAGNESIUM SALT
- CALCIMYCIN HEMIMAGNESIUM SALT
- CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT
- calcium ionophore A23187 hemimagnesium
- CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT BIOCHEMIKA
- a23187hemimagnesium salt
- A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt
- Calcimycin hemimagnesium
- CAS:
- 72124-77-7
- MF:
- C58H72MgN6O12
- MW:
- 1069.55
- Mol File:
- 72124-77-7.mol
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Chemical Properties
- storage temp.
- 2-8°C
- solubility
- acetone: 5 mg/mL, clear, faintly yellow
- BRN
- 6765085
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- F
- 8
MSDS
- Language:English Provider:SigmaAldrich
CALCIMYCIN A23187 HEMIMAGNESIUM SALT Usage And Synthesis
Uses
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4].
in vivo
Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].
| Animal Model: | Mice (ICR, 25-30 g)[5] |
| Dosage: | 2.5 or 7.5 nM |
| Administration: | Intrapleurally |
| Result: | Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values. |
References
[1] Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82. DOI:10.1128/AAC.01130-10
[2] Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94. DOI:10.1038/sj.embor.embor722
[3] Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90. DOI:10.4161/auto.25900
[4] Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200. DOI:10.1016/j.bbagen.2017.09.010
[5] Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5. DOI:10.1007/BF00180016
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