1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID Chemical Properties

Melting point:

117 °C(Solv: hexane (110-54-3); ethyl ether (60-29-7))

Boiling point:

386.6±42.0 °C(Predicted)

Density 

1.430±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

4.27±0.20(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

HazardClass 

IRRITANT

HS Code 

2933399990

1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID Usage And Synthesis

Synthesis

Example 17A1 Synthesis of 1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid: to a solution of piperidine-4-carboxylic acid (4 g, 30.97 mmol) in dichloromethane (20 mL) was added slowly and dropwise to trifluoromethanesulfonic anhydride (7.8 g) at 0 °C. The reaction mixture was stirred at 0 °C overnight. After completion of the reaction, the reaction solution was diluted with water, the organic layer was separated and concentrated. The crude product was purified by silica gel column chromatography to afford the title compound in 70% yield as a white solid.

References

[1] Patent: WO2013/10453, 2013, A1. Location in patent: Page/Page column 109

1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID(126501-70-0)Related Product Information

• 1-(Trifluoroacetyl)-2-piperidinecarboxylic acid butyl ester
• 1-(Trifluoroacetyl)-2-piperidinecarboxylic acid 1-methylpropyl ester
• 1-(Trifluoroacetyl)-4-piperidinecarboxylic acid (S)-1-methylpropyl ester
• 4-(TRIFLUOROACETYLAMINO)-1-BUTANOL
• Piperidine, 1-(fluoroacetyl)- (6CI,7CI,8CI,9CI)
• 4-PIPERIDINEMETHANOL, 1-(2-FLUOROETHYL)
• 1-(2,2,2-TRIFLUOROACETYL)-4-PIPERIDINECARBOXYLIC ACID
• 1-TRIFLUOROACETYL PIPERIDINE
• N,N-DIETHYL-2,2,2-TRIFLUOROACETAMIDE