L-R4W2
L-R4W2 Basic information
- Product Name:
- L-R4W2
- Synonyms:
-
- L-R4W2
- L-Tryptophanamide, L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-tryptophyl- (9CI)
- (2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-Amino-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-car bamimidamido-N-[(1S)-1-{[(1S)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]pentanamide
- CAS:
- 206350-79-0
- MF:
- C46H71N21O6
- MW:
- 1014.19
- Product Categories:
-
- Vanilloid/TRPV channel
- Mol File:
- 206350-79-0.mol
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L-R4W2 Chemical Properties
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- pka
- 13.31±0.46(Predicted)
- form
- Powder
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- Arg-Arg-Arg-Arg-Trp-Trp-NH2
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L-R4W2 Usage And Synthesis
Uses
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 may act as a potent analgesic[1][2].
IC 50
TRPV1: 0.1 μM (IC50)
References
[1] Planells-Cases R, et, al. Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 2000 Sep 15; 481(2): 131-6. DOI:10.1016/s0014-5793(00)01982-7
[2] Himmel HM, et, al. The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 2002 Jun; 301(3): 981-6. DOI:10.1124/jpet.301.3.981
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