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BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2

Basic information Safety Supplier Related

BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2 Basic information

Product Name:
BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
Synonyms:
  • (B-MERCAPTO-B,B-CYCLOPENTAMETHYLENE-*PRO PIONYL1,O-E
  • [β-mercapto-β,β-cyclopentamethylenepropionyl1, o-et-tyr2, val4, arg8]-vasopressin
  • 1-(1-MERCAPTOCYCLOHEXANEACETIC ACID)-2-(O-ETHYL-L-TYROSINE)-4-L- VALINE-8-L-ARGININEVASOPRESSIN
  • vasopressin 1-(1-MCHA)-2-(O-ethyl-L-tyrosine)-4-L-valine
  • BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
  • [BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENEPROPIONYL1,O-ET-TYR2,VAL4,ARG8]-VASOPRESSIN
  • (D(CH2)(5/1),TYR(ET)2,VAL4,ARG8)-VASOPRESSIN
  • [1-MERCAPTOCYCLOHEXYL]ACETYL-TYR[O-ETHYL]-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
CAS:
77453-01-1
MF:
C53H77N13O11S2
MW:
1136.39
Product Categories:
  • Vasopressin and Oxytocin receptor
  • Hormones
  • Oxytocin&Vasopressin
  • Pituitary Hormones
  • VasopressinPeptides for Cell Biology
  • Vasopressins
Mol File:
77453-01-1.mol
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BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2 Chemical Properties

storage temp. 
−20°C
form 
Solid
color 
White to off-white
Sequence
{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: 1-Cys6)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20
Safety Statements 
36
WGK Germany 
3

MSDS

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BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2 Usage And Synthesis

Uses

SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1].

in vivo

SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP[1].
SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP[1].

Animal Model:Male Sprague-Dawley rats (250-300 g)[1]
Dosage:8 μg/kg
Administration:Intravenous injection
Result:Completely blocked the antidiuretic effect of exogenous AVP (4 ng/kg body wt i.v.).

References

[1] S Ishikawa, et al. Further in vivo evidence for antagonist-to-antidiuretic action of arginine vasopressin. Am J Physiol. 1983 Nov;245(5 Pt 1):R713-9. DOI:10.1152/ajpregu.1983.245.5.R713

BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2Supplier

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025-58361106-805 15951641583
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0571-87213919
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BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2(77453-01-1)Related Product Information