TERT-BUTYL-D9-AMINE Chemical Properties

Melting point:

-67 °C (lit.)

Boiling point:

46 °C (lit.)

Density 

0.933 g/mL at 25 °C

refractive index 

n20/D 1.401(lit.)

Flash point:

16 °F

storage temp. 

0-6°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Oil

color 

Colourless to Yellow

Stability:

Volatile

InChI

1S/C4H11N/c1-4(2,3)5/h5H2,1-3H3/i1D3,2D3,3D3

InChIKey

YBRBMKDOPFTVDT-GQALSZNTSA-N

SMILES

[2H]C([2H])([2H])C(N)(C([2H])([2H])[2H])C([2H])([2H])[2H]

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-20/22-35

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3286 3/PG 2

WGK Germany 

3

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
Flam. Liq. 2
Skin Corr. 1A

MSDS

• Language:English Provider:SigmaAldrich

TERT-BUTYL-D9-AMINE Usage And Synthesis

Chemical Properties

Clear Colourless Oil

Uses

tert-Butylamine is common reagent in pharmaceuticals syntheses. Used in the preparation of aminoBODIPY compounds for chemical analyses. Also it aids in the synthesis of benzylurea-based insecticides c ontaining amide and sulfonate groups. It has also been used in the synthesis of BPTES analogs, that act as glutaminase inhibitors, which can attenuate the growth of human lymphoma B cells. This is the labeled analog.

Synthesis

In a 100 mL flask with a thermometer and condenser tube, 3.607 g (0.1 mol) of methanol-D4 was added and cooled to 0 C. Under stirring conditions, 38.071 g (0.15 mol) of iodine, and an appropriate amount of red phosphorus were added slowly in batches, and at the end of the reaction, was obtained by distillation. of iodomethane-D3, and then use the above-prepared iodomethane-D3 to prepare into a format reagent, and slowly add 6.412 g of dropwise at 2 ??C (0.1 mol) acetone-D6, and the reaction was carried out at room temperature for 3 h. The reaction was quenched by dilute hydrochloric acid to obtain tert-butanol-D6. The obtained tert-butanol-D6 was distilled After purification, the reaction temperature was controlled at -10 ??, 7.722 g (0.15 mol) of iminium chloride was added dropwise to tert-butanol-D6 and the catalyst, and the dropwise was added. After the addition was completed, the reaction was continued for 2h, and the reaction solution was distilled to obtain 3.734g of tert-butylamine-D9 product, with a yield of by methanol-D4 45.4% in methanol-D4, the chromatographic purity was more than 99.0%, and the abundance of D isotope was 98.8atom%D by mass spectrometry.

TERT-BUTYL-D9-AMINE(6045-08-5)Related Product Information

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