4-AMINO-1-N-BUTOXYCARBONYL-4-METHYL-PIPERIDINE Chemical Properties

Boiling point:

283℃

Density 

1.017

Flash point:

125℃

storage temp. 

2-8°C(protect from light)

pka

9.77±0.20(Predicted)

Appearance

Colorless to light yellow Solid-Liquid Mixture

Safety Information

HS Code 

29333990

4-AMINO-1-N-BUTOXYCARBONYL-4-METHYL-PIPERIDINE Usage And Synthesis

Chemical Properties

White powder

Synthesis

General procedure for the synthesis of tert-butyl 4-amino-4-methylpiperidine-1-carboxylate from the compound (CAS: 236406-14-7): a mixture of the compound of formula LE (2.48 g, 7.11 mmol) with 10% palladium carbon (200 mg, Sigma-Aldrich) in methanol (20 mL) was subjected to an atmosphere of hydrogen at about 250 °C The reaction was stirred for 16 hours. Upon completion of the reaction, the Pd/C catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give 1.37 g of the compound of formula LF as a light-colored viscous oil (90.2% yield). The structure of tert-butyl 4-amino-4-methylpiperidine-1-carboxylate, compound of formula LF, was confirmed using 1H NMR. The 1H NMR data of compound LF were as follows: δH (400 MHz, CDCl3): 3.47-3.49 (4H, m), 1.47-1.61 (4H, m), 1.46 (9H, s), 1.31-1.42 (2H, m), 1.15 (3H, s).

References

[1] Patent: WO2008/89201, 2008, A2. Location in patent: Page/Page column 234-235
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 12, p. 5901 - 5921
[3] Patent: WO2006/38006, 2006, A2. Location in patent: Page/Page column 26-27
[4] Patent: WO2009/116067, 2009, A2. Location in patent: Page/Page column 139

4-AMINO-1-N-BUTOXYCARBONYL-4-METHYL-PIPERIDINE(343788-69-2)Related Product Information

• 4-Amino-1-Boc-2-methylpiperidine
• 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID
• 4-AMINO-1-N-BUTOXYCARBONYL-4-METHYL-PIPERIDINE
• 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
• 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
• 1-Boc-4-amino-4-piperidineacetic acid
• TERT-BUTYL 4-[ACETYL(METHYL)AMINO]-4-PHENYLPIPERIDINE-1-CARBAMATE
• 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXAMIDE
• TERT-BUTYL 4-AMINO-4-CYANOPIPERIDINE-1-CARBOXYLATE
• 1-T-BOC-PIPERIDINE-4-SPIRO-5'-HYDANTOIN
• 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE
• 1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN
• (4-FMOC-AMINO-1-BOC-PIPERIDIN-4-YL)-ACETIC ACID
• 1-BOC-4-[4-(METHYLSULFONYL)-2-NITROPHENYL]PIPERIDIN-4-AMINE
• 4-AMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-METHYL ESTER
• 4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE
• 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
• BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE