FM479
FM479 Basic information
- Product Name:
- FM479
- Synonyms:
-
- FM479
- 2-Propenamide, 2-cyano-3-[5-(1-cyclohexyl-1,6-dihydro-6-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furanyl]-N,N-dimethyl-
- 2-Cyano-3-(5-(1-cyclohexyl-6-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
- (E)-2-Cyano-3-[5-(1-cyclohexyl-6-methyl-1,6-dihydro-1,3,5,6-tetraaza-aS-indacen-2-yl)-furan-2-yl]-N,N-dimethyl-acrylamide
- CAS:
- 2226521-64-6
- MF:
- C25H26N6O2
- MW:
- 442.51
- Mol File:
- 2226521-64-6.mol
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FM479 Chemical Properties
- Boiling point:
- 735.7±70.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 2mg/mL, clear
- pka
- 6.39±0.40(Predicted)
- form
- powder
- color
- yellow to orange
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FM479 Usage And Synthesis
Uses
FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of?JAK3?targeting the unique Cys909. FM-381 has an?IC50?of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Biological Activity
FM-479 is a negative control for FM-381 (HY-102046) and has no activity against JAK3 or other kinases. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting unique Cys909.
in vitro
FM-479 is the inactive control of FM-381, the concentration used in assays is similar.
target
| JAK3
|
IC 50
JAK3
References
[1] https://www.thesgc.org/chemical-probes/FM-381
FM479Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
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- 021-31433387 15618786686
- sales@rechemscience.com
Shanghai Chaolan Chemical Technology Center
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- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Shanghai SuperLan Chemcial Technique Centre
- Tel
- 0-2022843681 15618226720
- chaolaichem@foxmail.com