3-BROMOBENZHYDRAZIDE Chemical Properties

Melting point:

157-159 °C (lit.)

Density 

1.615±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder to crystal

pka

11.86±0.10(Predicted)

color 

White to Almost white

Water Solubility 

Slightly soluble in water (3.7 g/L) (25°C)

BRN 

1945814

InChI

1S/C7H7BrN2O/c8-6-3-1-2-5(4-6)7(11)10-9/h1-4H,9H2,(H,10,11)

InChIKey

BNAQRAZIPAHWAR-UHFFFAOYSA-N

SMILES

NNC(=O)c1cccc(Br)c1

CAS DataBase Reference

39115-96-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29280000

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:ALFA

3-BROMOBENZHYDRAZIDE Usage And Synthesis

Uses

3-Bromobenzhydrazide is used to produce 5-(3-bromo-phenyl)-3H-[1,3,4]oxadiazole-2-thione. This reaction will need reagent potassium hydroxide and solvent ethanol.

Synthesis

General procedure for the synthesis of 3-bromobenzoic acid hydrazide from ethyl 3-bromobenzoate: Hydrazide was synthesized routinely using the one-pot method (30-58% yield). Ethyl 3-bromobenzoate (10 mmol) was dissolved in ethanol (20 mL). 3N sulfuric acid (2 mL) was added to the solution and the reaction mixture was refluxed for 6 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized by addition of solid sodium bicarbonate (NaHCO3) and filtered to remove excess NaHCO3. To the neutralized reaction mixture, hydrazine monohydrate (1.5 mL, 3 mmol) was added and refluxing was continued for 3-6 hr to ensure the reaction was complete. The volume of the reaction mixture was reduced to 1/3 of the original volume by distillation to remove ethanol and unreacted hydrazine monohydrate. The reaction mixture was cooled to room temperature, the precipitate was collected by filtration and recrystallized from methanol to give pure 3-bromophenylhydrazine crystals (see Supporting Information for specific data).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6014 - 6024
[2] Patent: US2007/149784, 2007, A1. Location in patent: Page/Page column 80-81
[3] Patent: EP1972625, 2008, A1. Location in patent: Page/Page column 19-20
[4] Patent: CN105481765, 2016, A. Location in patent: Paragraph 0090; 0091; 0092
[5] Journal of the Chinese Chemical Society (Peking), 1936, vol. 4, p. 69,72

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