4-BROMOBENZHYDRAZIDE Chemical Properties

Melting point:

167-169°C

Density 

1.615±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Powder

pka

12.09±0.10(Predicted)

color 

Light beige

Water Solubility 

Soluble in hot methanol (almost transparency). Slightly soluble in water.

BRN 

777006

InChI

InChI=1S/C7H7BrN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)

InChIKey

UYIMBYKIIMYFPS-UHFFFAOYSA-N

SMILES

C(NN)(=O)C1=CC=C(Br)C=C1

CAS DataBase Reference

5933-32-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

WGK Germany 

3

RTECS 

DG4449250

HS Code 

29280000

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

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4-BROMOBENZHYDRAZIDE Usage And Synthesis

Chemical Properties

Light beige powder

Uses

4-Bromobenzoic hydrazide has been used in the preparation of {2-[1-oxo-3-(4-bromophenyl)-2-propenyl]hydrazide}-4-bromobenzoic acid, {2,2?-[1,4-phenylenebis(1-oxo-2-propene-3,1-diyl)]dihydrazide}-p-bromobenzoic acid and substituted period[1,2-a]pyrimidine-2,4(3H)-diones (PPMDO).

Synthesis

To a 250 mL three-necked vial was added p-bromobenzoic acid (10.0 g, 49.75 mmol) and 100 mL Tetrahydrofuran, then add N,N'-carbonyl diimidazole (10.45g, 64.68mmol), TLC to monitor whether the raw material reaction is complete, after the reaction is complete, slowly add 80% hydrazine hydrate (4.93g, 78.77mmol) dropwise, dropwise, stirring the reaction for about 6 h. TLC to monitor whether the raw material reaction is complete (Expanding agent: petroleum ether /Ethyl acetate 1:1). After the reaction was completed, cooled to room temperature, concentrated under reduced pressure to remove most of the organic solvent, added about 30mL of water, pulsed at room temperature for a few moments, filtration, washed with water, resulting in a white flaky solid. After 15mL Anhydrous ethanol recrystallization yielded 9.09 g of white solid of Intermediate 3 in 85% yield. m.p. 166-167??C, consistent with literature values.

4-BROMOBENZHYDRAZIDE(5933-32-4)Related Product Information

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