KHSRP ANTIBODY Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

KHSRP, also known as KSRP, is a KH domain-containing AU-rich element binding protein. It recruits degradation machinery and activates mRNA turnover. This protein was previously shown to function as a regulator for splicing. KHSRP associates with both the Drosha and Dicer multiprotein complexes, and controls the biogenesis of some microRNAs by binding to the terminal loops of these microRNA precursors. KHSRP is found in neural and non-neural cell types in both the nucleus and the cytoplasm.

References

[1] Gherzi, R. et al. (2006) PLoS Biol 5, e5.
[2] Gherzi, R. et al. (2004) Mol Cell 14, 571-83.
[3] Min, H. et al. (1997) Genes Dev 11, 1023-36.
[4] Trabucchi, M. et al. (2009) Nature 459, 1010-4.

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