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Nintedanib Impurity L
Nintedanib Impurity L Basic information
- Product Name:
- Nintedanib Impurity L
- Synonyms:
-
- Nintedanib Impurity L
- (E)-methyl 1-acetyl-2-oxo-3-(phenyl(piperidin-1-yl)methylene)indoline-6-carboxylate
- (3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-5-carboxylic acid methyl ester
- Nintedanib impurity 24/(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-5-carboxylic acid methyl ester
- MELK inhibitor 17
- MELK-IN-1
- 1H-Indole-5-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-
- inhibit,MELK,Inhibitor,MELK IN 1,MELKIN1,Maternal embryonic leucine zipper kinase
- CAS:
- 2095596-44-2
- MF:
- C31H33N5O4
- MW:
- 539.64
- Mol File:
- 2095596-44-2.mol
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Nintedanib Impurity L Chemical Properties
- Boiling point:
- 750.8±60.0 °C(Predicted)
- Density
- 1.284±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 11.24±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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Nintedanib Impurity L Usage And Synthesis
Uses
MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.
References
[1] Edupuganti R, et al. Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem. 2017 May 1;25(9):2609-2616. DOI:10.1016/j.bmc.2017.03.018
Nintedanib Impurity LSupplier
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