Lascufloxacin hydrochloride Usage And Synthesis

Uses

Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.

Biological Activity

Lascufloxacin hydrochloride has potent activity against a broad range of pathogens, including aerobic and anaerobic strains, and is able to inhibit both wild-type and mutant targets, making it effective against fluoroquinolone-resistant bacterial strains.

Synthesis

The synthesis of Lascufloxacin hydrochloride can follow the route below

References

[1] In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977) DOI:10.1128/AAC.00120-17