4-BROMO-A23187 Chemical Properties

Boiling point:

735.4±60.0 °C(Predicted)

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

ethanol: 20 mg/mL

pka

15.14±0.50(Predicted)

form 

powder

color 

yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39-36/37

WGK Germany 

3

HS Code 

29419090

MSDS

• Language:English Provider:SigmaAldrich

4-BROMO-A23187 Usage And Synthesis

Chemical Properties

Yellow powder

Uses

4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca²⁺/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.

Uses

4-Bromo-A23187 is an ionophore that transports Zn2+ and Mn2+ with high selectivity over Ca2+.

Biochem/physiol Actions

4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.

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