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AMITRIPTYLINE METABOLITE (+/-)-

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AMITRIPTYLINE METABOLITE (+/-)- Basic information

Product Name:
AMITRIPTYLINE METABOLITE (+/-)-
Synonyms:
  • (11E)-11-[3-(dimethylamino)propylidene]-5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-5-ol
  • AMITRIPTYLINE METABOLITE (+/-)-
  • AMITRIPTYLINE METABOLITE (+-)-(E)-10-HYD ROXYLA
  • 5H-Dibenzo[a,d]cyclohepten-10-ol, 5-[3-(dimethylamino)propylidene]-10,11-dihydro-, (5E)-
  • 10-Hydroxy (E)-Amitriptyline
  • Amitriptyline metabolite, (±)-E-10-hydroxylated-
  • (E)-5-(3-(Dimethylamino)propylidene)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol
CAS:
64520-05-4
MF:
C20H23NO
MW:
293.4
Mol File:
64520-05-4.mol
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AMITRIPTYLINE METABOLITE (+/-)- Chemical Properties

Melting point:
97-99 °C
Boiling point:
453.3±45.0 °C(Predicted)
Density 
1.151±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
0.1 M HCl: soluble
form 
solid
pka
13.89±0.20(Predicted)
color 
white
Stability:
Hygroscopic
EPA Substance Registry System
5H-Dibenzo[a,d]cyclohepten-10-ol, 5-[3-(dimethylamino)propylidene]-10,11-dihydro-, (5E)- (64520-05-4)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
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AMITRIPTYLINE METABOLITE (+/-)- Usage And Synthesis

Uses

(5E)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is a metabolite of amitriptyline (A633350) which is a dibenzocycloheptadiene derivative and an antidepressant (1). Amitriptyline is also a TrkA and TrkB receptor agonist and exhibits neurotrophic and anti-inflammatory activities (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA).

Definition

ChEBI: E-10-Hydroxyamitriptyline is an organic tricyclic compound.

Biochem/physiol Actions

Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.

AMITRIPTYLINE METABOLITE (+/-)-Supplier

Sigma-Aldrich
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