Eslicarbazepine Chemical Properties

Melting point:

188-190°C

Boiling point:

431.3±55.0 °C(Predicted)

Density 

1.336

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly, Heated), Methanol (Slightly), Pyridine (Slightly)

form 

Solid

pka

13.75±0.20(Predicted)

color 

White to Pale Yellow

InChI

InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m0/s1

InChIKey

BMPDWHIDQYTSHX-AWEZNQCLSA-N

SMILES

N1(C(N)=O)C2=CC=CC=C2[C@@H](O)CC2=CC=CC=C12

Eslicarbazepine Usage And Synthesis

Description

Eslicarbazepine (also known as (S)-10-Monohydroxy-10,11-dihydro Carbamazepine) is a voltage-gated sodium channel (Nav) inhibitor and the active metabolite of the prodrug eslicarbazepine acetate. It enhances the slow activation of voltage-gated sodium channels, thereby reducing channel availability. Eslicarbazepine is an oral anticonvulsant used as an adjunctive treatment for partial-onset seizures.

Chemical Properties

Off-White Solid

Uses

An optically active metabolite of carbamazepine

Uses

A metabolite of Eslicarbazepine acetate, (BIA 2-093) a novel central nervous system drug.

Uses

(S)-10-Monohydroxy-10,11-dihydro Carbamazepine is the metabolite of Eslicarbazepine acetate, (BIA 2-093), (E659000) a novel central nervous system drug.

Definition

ChEBI: (S)-MHD is a dibenzooxazepine.

Eslicarbazepine(104746-04-5)Related Product Information

• Eslicarbazepine
• Carbamazepine
• BIA 2-093
• rac trans-10,11-Dihydro-10,11-dihydroxy Carbamazepine
• 10,11-DIHYDROCARBAMAZEPINE
• Oxcarbazepine