ALDH1A2 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse

Background

The aldehyde dehydrogenase family is a large group of enzymes that catalyze the oxidization of aldehydes into carboxylic acids. Aldehyde Dehydrogenase 1A2 is among a group of aldehyde dehydrogenases that catalyze the metabolism of retinaldehyde into retinoic acid, which plays a critically important signaling role in animal development. Research studies have shown that ALDH1A2 also plays a role postnatally in modulating the effects of RA signaling on immune cell function. In one example using a genetic mouse model, it was shown that ALDH1A2-dependent RA signaling was a downstream mediator of NOTCH-dependent T cell differentiation.

References

[1] Jackson, B. et al. (2011) Hum Genomics 5, 283-303.
[2] Means, A.L. and Gudas, L.J. (1995) Annu Rev Biochem 64, 201-33.
[3] Dalmas, E. et al. (2017) Immunity 47, 928-942.e7.
[4] Shiokawa, A. et al. (2017) Immunology 152, 52-64.
[5] Yokota-Nakatsuma, A. et al. (2016) Sci Rep 6, 37914.
[6] Zaman, T.S. et al. (2017) J Immunol 199, 1989-97.

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