RO 106-9920
RO 106-9920 Basic information
- Product Name:
- RO 106-9920
- Synonyms:
-
- RO 106-9920
- TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE
- 6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE
- Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)-
- Ro 106-9920 DISCONTINUED
- Ro 106 9920,Ro 1069920
- Ro 106-9920, NF-kappaB inhibitor
- CAS:
- 62645-28-7
- MF:
- C10H7N5OS
- MW:
- 245.26
- Product Categories:
-
- Cytokine signaling
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 62645-28-7.mol
RO 106-9920 Chemical Properties
- storage temp.
- Store at +4°C
- solubility
- Soluble to 5 mM in ethanol and to 100 mM in DMSO
- form
- White solid
- color
- White to off-white
RO 106-9920 Usage And Synthesis
Uses
Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
Definition
ChEBI: 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine is a sulfoxide.
Biological Activity
Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
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