NAPHTHOL AS-E PHOSPHATE
NAPHTHOL AS-E PHOSPHATE Basic information
- Product Name:
- NAPHTHOL AS-E PHOSPHATE
- Synonyms:
-
- NAPHTHOL AS-E PHOSPHATE
- N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide
- NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY
- NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE
- N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide
- [3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate
- kg-501
- N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE; KG-501; NASEP;NAPHTHOL AS-E PHOSPHATE;KG501;KG 501
- CAS:
- 18228-17-6
- MF:
- C17H13ClNO5P
- MW:
- 377.72
- EINECS:
- 242-106-1
- Product Categories:
-
- Substrates
- API
- Mol File:
- 18228-17-6.mol
NAPHTHOL AS-E PHOSPHATE Chemical Properties
- Density
- 1.567±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: soluble
- form
- A crystalline solid
- pka
- 1.04±0.30(Predicted)
- color
- White to light yellow
- BRN
- 6664478
Safety Information
- WGK Germany
- 3
- F
- 8-10-21
MSDS
- Language:English Provider:SigmaAldrich
NAPHTHOL AS-E PHOSPHATE Usage And Synthesis
Biological Activity
Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.
in vitro
Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.
in vivo
Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.