Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Vitamins and Minerals medicines >  Vitamin C drugs >  Menadione sodium bisulfite

Menadione sodium bisulfite

Basic information Safety Supplier Related

Menadione sodium bisulfite Basic information

Product Name:
Menadione sodium bisulfite
Synonyms:
  • VITAMIN K3 SODIUM BISULFITE
  • 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonicacidsodiumsalt
  • 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonicacisodiumsalt
  • 2-METHYL-1,4-NAPHTHOQUINONE SODIUM BISULFATE
  • 2-METHYL-1,4-NAPHTHOQUINONE SODIUM BISULFITE
  • MENADIONE SODIUM BISULFITE
  • Menadione sodium hydrogen sulfite
  • 2-Methyl-1,4-naphthoquinone sodium bisulfite trihydrate
CAS:
130-37-0
MF:
C11H9NaO5S
MW:
276.24
EINECS:
204-987-0
Product Categories:
  • Pharmaceutical intermediates
Mol File:
130-37-0.mol
More
Less

Menadione sodium bisulfite Chemical Properties

Melting point:
121-124°C
storage temp. 
-20°C
solubility 
H2O: ≥50mg/mL, clear, colorless to faintly yellow
EPA Substance Registry System
Menadione sodium bisulfite (130-37-0)
More
Less

Safety Information

Hazard Codes 
Xi,N
Risk Statements 
36-50/53-36/38
Safety Statements 
26-61-60-24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

MSDS

More
Less

Menadione sodium bisulfite Usage And Synthesis

Chemical Properties

white powder

Originator

Kavitol,Lannacher Heilmittel

Definition

ChEBI: An organic sodium salt that is the monosodium salt of menadione sulfonate. A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation i vivo.

Manufacturing Process

The 2-naphthalenesulfonic acid, 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-, sodium salt, trihydrate can be prepared by mixing the 2-methyl-1,4- naphthoquinone with the bisulphite salt in the presence of water. Ordinarily gentle warming of the aqueous mixture is preferred to facilitate solution. The mixture of 2-methyl-1,4-naphthoquinone (250 mg; 1 molar equivalent); sodium bisulphite (149 mg; 1 molar equivalent); distilled water (250 ml) or 2- methyl-1,4-naphthoquinone (250 mg; 1 molar equivalent); potassium bisulphate (349 mg; 2 molar equivalent); distilled water 250 ml may be used. These examples representing preferred ratios of ingredients are merely illustrative and are not to be interpreted as limiting.
The bisulphite addition compounds have been found to be stable in sunlight and also to be heat stable. Tests, for example, carried out in ampoules have shown aqueous solutions of the compounds not to be decomposed after exposure to a month's sunlight, while other tests have shown the solutions of such compounds to retain their original potency (a) when stored in an oven at 60°C for 15 days or (b) when sterilized at 15 pounds for 0.5 hour in an autoclave at about 122°C. These properties emphasize the radical differences between the stable salts and the properties of 2-methyl-1,4-naphthoquinone, the characteristic instability of which is illustrated by its sensitivity, i. e., decomposition, when exposed to light.
The bisulphite addition compounds have a vitamin K activity equal to that of the 2-methyl-1,4-naphthoquinone contained in the molecule. The compounds, although suitable for oral administration, are particularly adaptable in aqueous solution for parenteral administration in the treatment of hemorrhagic conditions.

brand name

Hykinone (Abbott); Klotogen (Abbott).

Therapeutic Function

Prothrombogenic vitamin

Menadione sodium bisulfiteSupplier

BEST-REAGENT Gold
Tel
400-1166-196;028-84555506- ;028-84555506-
Email
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Email
sales@jonln.com;sales@jonln.com
Nanjing Chemlin Chemical Co., Ltd
Tel
Email
info@chemlin.com.cn
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Email
sale@xiyashiji.com;3007716753@qq.com