Basic information Safety Supplier Related

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

Basic information Safety Supplier Related

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Basic information

Product Name:
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
Synonyms:
  • 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
  • CHEMBRDG-BB 9070724
  • 2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
  • Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
  • Brn 2857211
  • N-(Dimethoxy-3,4 benzyl)-chloroacetamide
  • N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
  • 2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
CAS:
65836-72-8
MF:
C11H14ClNO3
MW:
243.69
EINECS:
604-604-1
Mol File:
65836-72-8.mol
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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Chemical Properties

Melting point:
116-118 °C(Solv: carbon tetrachloride (56-23-5))
Boiling point:
425.7±45.0 °C(Predicted)
Density 
1.194±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 150 mg/mL (615.54 mM)
form 
Solid
pka
13.42±0.46(Predicted)
color 
White to light yellow
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Safety Information

Hazard Codes 
Xi
HazardClass 
IRRITANT
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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Usage And Synthesis

Biological Activity

DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM.

in vitro

Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.

in vivo

DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.

target

IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDESupplier

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