2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Basic information
- Product Name:
- 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- Synonyms:
-
- 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- CHEMBRDG-BB 9070724
- 2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
- Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
- Brn 2857211
- N-(Dimethoxy-3,4 benzyl)-chloroacetamide
- N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
- 2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
- CAS:
- 65836-72-8
- MF:
- C11H14ClNO3
- MW:
- 243.69
- EINECS:
- 604-604-1
- Mol File:
- 65836-72-8.mol
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Chemical Properties
- Melting point:
- 116-118 °C(Solv: carbon tetrachloride (56-23-5))
- Boiling point:
- 425.7±45.0 °C(Predicted)
- Density
- 1.194±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (615.54 mM)
- pka
- 13.42±0.46(Predicted)
Safety Information
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Usage And Synthesis
Biological Activity
DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM.
in vitro
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
in vivo
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
target
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDESupplier
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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE(65836-72-8)Related Product Information
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- 2-CHLORO-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHYL)-N-METHYLACETAMIDE
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- N-[4-(BENZYLOXY)-3-METHOXYBENZYL]-2-CHLOROACETAMIDE