TIMTEC-BB SBB005393 Chemical Properties

Melting point:

222-227 °C

storage temp. 

room temp

solubility 

DMSO: >10mg/mL

form 

White solid

color 

white to off-white

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2930909899

TIMTEC-BB SBB005393 Usage And Synthesis

Uses

RRD-251 Hydrochloride is a reversible selective disruptor of Rb-Raf-1 interaction.

Biological Activity

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

in vivo