Pomalidomide-PEG3-NH2 Chemical Properties

Boiling point:

760.8±60.0 °C(Predicted)

Density 

1.415±0.06 g/cm3(Predicted)

pka

10.68±0.40(Predicted)

Pomalidomide-PEG3-NH2 Usage And Synthesis

Uses

Pomalidomide-amino-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

Pomalidomide-PEG3-NH2(2380273-74-3)Related Product Information

• POMALIDOMIDE-PEG2-ALKYNE
• Pomalidomide-PEG2-NH2
• Pomalidomide-PEG6-Alkyne
• POMALIDOMIDE-PEG2-CO2H
• Pomalidomide-PEG6-NH2
• Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-