1-(2-METHYLPYRIDIN-4-YL)ETHANONE Chemical Properties

Melting point:

149 °C

Boiling point:

130 °C(Press: 4 Torr)

Density 

1.036±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

4.25±0.10(Predicted)

Appearance

Light yellow to light brown Solid-Liquid Mixture

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37

Safety Statements 

26-36/37

HS Code 

2933399990

1-(2-METHYLPYRIDIN-4-YL)ETHANONE Usage And Synthesis

Definition

ChEBI: 4-Acetyl-2-methylpyridine is an aromatic ketone.

Synthesis

Step 3: Synthesis of 1-(2-methylpyridin-4-yl)ethanone (46d) To a stirred tetrahydrofuran (THF) solution (520 mL) of N-methoxy-N,2-dimethylisonicotinamide (46c) (26 g, 144.28 mmol) under nitrogen protection, methyl lithium (MeLi, 6.342 g, 288.562 mmol, 1M THF solution) was slowly added at -78 °C. The reaction mixture was gradually warmed to room temperature over a period of 1 h, followed by quenching the reaction with saturated ammonium chloride (NH4Cl) solution at 0 °C. The reaction mixture was extracted with ethyl acetate, the organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was purified by column chromatography to afford 1-(2-methylpyridin-4-yl)ethanone (46d) (11 g, 56.4% yield) as a slightly red viscous liquid. 1H NMR (CDCl3) δ: 8.61-8.59 (d, 1H), 7.51-7.45 (d, 1H), 7.45-7.44 (m, 1H), 4.05-4.02 (s, 3H). MS (ES+): 136.1 (M + 1).

References

[1] Patent: WO2015/134998, 2015, A1. Location in patent: Page/Page column 840; 841
[2] Patent: WO2017/59178, 2017, A1. Location in patent: Page/Page column 151
[3] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 141; 142
[4] Patent: WO2013/19626, 2013, A1. Location in patent: Page/Page column 34; 35

1-(2-METHYLPYRIDIN-4-YL)ETHANONE(2732-28-7)Related Product Information

• 1-(2-Methylpyridin-3-yl)ethanone
• 1-(2-fluoro-3-nitrophenyl)ethanone
• 1-(3-BROMO-2-METHYLPYRIDIN-4-YL)ETHANONE
• 3-(2-PHENYL-QUINOLINE-4-CARBONYL)-1-VINYL-PYRROLIDIN-2-ONE
• [2,2'-BIPYRIDIN]-4-YL-PHENYL-METHANONE
• AURORA KA-8155
• 1-(6-Methyl-2-phenyl-4-quinolinyl)-2-(4-piperidinyl)ethanone
• 4-Acetyl-2-cyanopyridine
• 1-(2-METHYLPYRIDIN-4-YL)ETHANONE
• 1-(3-AMINO-2-METHYLPYRIDIN-4-YL)ETHANONE
• 3-(2-PHENYL-QUINOLINE-4-CARBONYL)-1-VINYL-AZEPAN-2-ONE
• bis[2,8-di(trifluoromethyl)quinolin-4-yl-2-pyridyl] ketone
• 3-(2-PHENYL-QUINOLINE-4-CARBONYL)-PIPERIDIN-2-ONE
• Ethanone, 1-(2,6-dimethyl-4-pyridinyl)- (9CI)
• bostrycoidin
• Cyclopropyl-(2-methyl-4-pyridinyl)-methanone