1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Chemical Properties

storage temp. 

Desiccate at RT

solubility 

DMSO: ≥10mg/mL

form 

powder

color 

off-white to light tan

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Usage And Synthesis

Uses

A highly selective histamine H4 receptor silent antagonist

Biological Activity

Highly selective histamine H 4 receptor silent antagonist; binds with high affinity to the human H 4 receptor (K i = 26 nM) and is > 540-fold selective over the H 3 receptor (K i = 14.1 μ M). In vitro, inhibits mast cell and eosinophil chemotaxis with IC 50 values of 138 and 530 nM respectively. Orally active in vivo .

storage

room temperature (desiccate)

1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE(869497-75-6)Related Product Information

• (6-CHLORO-1H-BENZOIMIDAZOL-2-YL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE
• 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
• 1H-BENZIMIDAZOLE-2-CARBOXALDEHYDE, 5-CHLORO-