1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Basic information
- Product Name:
- 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
- Synonyms:
-
- JNJ 10191584 MALEATE
- 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE
- VUF 6002
- JNJ 10191584 maleate salt
- VUF 6002 maleate
- VUF6002 maleate
- JNJ 10191584 maleate (VUF 6002)
- JNJ 10191584 maleate (VUF 6002), Selective H4 antagonist
- CAS:
- 869497-75-6
- MF:
- C17H19ClN4O5
- MW:
- 394.80956
- Product Categories:
-
- Other Enzyme Inhibitors and Activators.
- Histamine
- Histamine receptor
- Other enzyme inhibitors and activators
- Mol File:
- 869497-75-6.mol
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1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Chemical Properties
- storage temp.
- Desiccate at RT
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- off-white to light tan
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Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
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1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATE Usage And Synthesis
Uses
A highly selective histamine H4 receptor silent antagonist
Biological Activity
Highly selective histamine H 4 receptor silent antagonist; binds with high affinity to the human H 4 receptor (K i = 26 nM) and is > 540-fold selective over the H 3 receptor (K i = 14.1 μ M). In vitro, inhibits mast cell and eosinophil chemotaxis with IC 50 values of 138 and 530 nM respectively. Orally active in vivo .
storage
room temperature (desiccate)
1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYLPIPERAZINE MALEATESupplier
J & K SCIENTIFIC LTD.
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