ZK 200775 Chemical Properties

Density 

1.615±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: ≥20mg/mL

pka

2.09±0.10(Predicted)

form 

powder

color 

off-white to light brown

Safety Information

WGK Germany 

3

HS Code 

2934999090

ZK 200775 Usage And Synthesis

Uses

ZK 200775 is a competitive AMPA/kainate antagonist. Neuronal protection against cerebral ischemia.

Biological Activity

Competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [ 3 H]-AMPA (K i = 120 nM) and [ 3 H]-CNQX (K i = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC 50 values range from 2.5 to 11 μ M). Inhibits currents induced by AMPA, kainate and NMDA with IC 50 values of 21 nM, 27 nM, and > 1 μ M respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo .

storage

Desiccate at +4°C

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