4-(3-BROMO-PHENYL)-1H-IMIDAZOLE Chemical Properties

Boiling point:

412.8±20.0 °C(Predicted)

Density 

1.565±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.21±0.10(Predicted)

Appearance

Off-white to light yellow Solid

4-(3-BROMO-PHENYL)-1H-IMIDAZOLE Usage And Synthesis

Synthesis

General method: α-Bromophenyl ketone derivative (1.34 mmol) was dissolved in formamide (10 mL) and the reaction was heated at 170-180°C for 5-10 hours. After completion of the reaction, the reaction solution was cooled to room temperature and diluted with saturated NaHCO3 solution (20 mL). Subsequently, the aqueous phase was extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, washed sequentially with water and saturated brine and dried over anhydrous Na2SO4. The organic phase was concentrated under reduced pressure to obtain the crude product. Finally, the crude product was purified by silica gel fast column chromatography to obtain the target compound 5-(3-bromophenyl)-1H-imidazole.

References

[1] Patent: US9174942, 2015, B2. Location in patent: Page/Page column 204

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