Sodium chloroacetate Chemical Properties

Melting point:

199 °C (dec.)(lit.)

Density 

1.87[at 20℃]

vapor pressure 

0.001Pa at 20℃

Flash point:

270°C

storage temp. 

-20°C

solubility 

820g/l

form 

Crystalline Powder

color 

White

PH

4.5-9.0 (50g/l, H2O, 20℃)

Water Solubility 

440 g/L (20 ºC)

Sensitive 

Hygroscopic

Merck 

14,2112

BRN 

3597157

Stability:

Stable. Incompatible with strong oxidizing agents.

LogP

-3.8 at 20℃

CAS DataBase Reference

3926-62-3(CAS DataBase Reference)

EPA Substance Registry System

Sodium chloroacetate (3926-62-3)

Safety Information

Hazard Codes 

T,N

Risk Statements 

25-38-50-36

Safety Statements 

22-37-45-61-26

RIDADR 

UN 2659 6.1/PG 3

WGK Germany 

2

RTECS 

AG1400000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29154000

Toxicity

LD50 orally in Rabbit: 95 mg/kg LD50 dermal Rat > 2000 mg/kg

MSDS

• Language:English Provider:Chloroacetic acid sodium salt
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Sodium chloroacetate Usage And Synthesis

description

Sodium chloroacetate is a white colored powdered solid. It is soluble in water. It may be toxic ingestion or inhalation. It is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.

In one study systemic effects to Sprague-Dawley rats (M/F, numbers per group not indicated) given single doses of sodium chloroacetate at 94, 282, or 470 mg/kg bw demonstrated increased sodium concentration in urine, increased potassium concentration in plasma, and reduced glutathione level in the liver at the highest dose; 2/3 of males died within 24 hours of treatment in the middle and high dose groups.

Stability and Reactivity:

Sodium chloroacetate is stable at normal temperatures and  pressures. Incompatible with oxidizing agents, reducing  agents.

HUMAN USE AND EXPERIENCE

There are a number of case studies of the parent compound,  monochloroacetic acid (MCA), involving corrosion of skin and  eyes and fatalities related to skin absorption of toxicologically  significant amounts of MCA and a health-based target  concentration of 0.1 mg/L was calculated for MCA in drinking  water although Health Canada and Environment Canada have  categorized MCA as not entering the environment at levels that  may be hazardous to human health. There are, however, no  similar data or epidemiological reports for sodium  chloroacetate.

Metabolism/Pharmacokinetics

After absorption, monochloroacetic acid (parent compound  CAS 79-11-8) is converted to thiodiacetic acid and glycolic acid  and is accumulated in the liver and kidneys of rats.Metabolism of sodium monochloroacetate is expected to have a  similar pharmacokinetic profile.

Chemical Properties

Sodium chloroacetate is a white crystalline powder. It is soluble in water. It may be toxic ingestion or inhalation.
Sodium chloroacetate is a reactive and toxic material, so it is hydrolyzed to glycolic acid nearly quantitatively at the end of the production cycle. Chloroacetic acid always contains traces of dichloroacetic acid, a toxic and unreactive material that appears on the California Prop.65 list.

Uses

Sodium chloroacetate is the sodium salt of chloroacetic acid. It is used to prepare weed killers, dyes, vitamins and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor. Sodium dihydroxyethyltallow glycinate is the condensation product of dihydroxyethyl tallow amine and sodiumchloroacetate.It is used as a thickeningagent and asurfactant.

Uses

Sodium chloroacetate is used to prepare dyes and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor.

General Description

Chloroacetic acid sodium salt is a white colored powdered solid. Chloroacetic acid sodium salt is soluble in water.Chloroacetic acid sodium salt may be toxic ingestion or inhalation. Sodium chloroacetate is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.

Air & Water Reactions

Chloroacetic acid sodium salt is soluble in water.

Reactivity Profile

Salts, basic, such as Chloroacetic acid sodium salt, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Actin plays an important role in cell motility, structure and integrity. Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and helps in vascular smooth muscle cell contraction. The encoded protein modulates the expression of c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Mutation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD).

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Cland NazO. Used as an herbicide

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