sultiame Chemical Properties

Melting point:

180-182°

Boiling point:

520.2±60.0 °C(Predicted)

Density 

1.472±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: slightly; Methanol: slightly

form 

A solid

pka

9.90±0.10(Predicted)

color 

White to off-white

InChI

InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)

InChIKey

HMHVCUVYZFYAJI-UHFFFAOYSA-N

SMILES

C1(S(N)(=O)=O)=CC=C(N2CCCCS2(=O)=O)C=C1

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

sultiame Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Sulthiame is a benzenesulfonamide derivative. Sulthiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy.

Uses

Sultiame is a benzenesulfonamide derivative. Sultiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy.

Definition

ChEBI: Sultiame is an organic molecular entity.

brand name

Conadil (3M Pharmaceuticals); Trolone (3M Pharmaceuticals).

Biological Activity

Sulthiame is a carbonic anhydrase (CA) inhibitor (hCA Ki in nM = 374/I, 7/II, 95/IV, 81/VA, 91/VB, 134/VI, 6/VII, 43/IX, 56/XII; Ki = 630 mM/hCA III, 1.45 μM/mCA XIII, 1.54 μM/hCA XIV) with anticonvulsant efficacy in vivo.

sultiame(61-56-3)Related Product Information

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