1,4-BUTANESULTAM Chemical Properties

Melting point:

74-84°C

Boiling point:

143-145 °C(Press: 0.8 Torr)

Density 

1.239±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

11.70±0.20(Predicted)

color 

White to Light yellow

InChI

InChI=1S/C4H9NO2S/c6-8(7)4-2-1-3-5-8/h5H,1-4H2

InChIKey

DNGMYXZLJGHHOM-UHFFFAOYSA-N

SMILES

S1(=O)(=O)CCCCN1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2941100000

1,4-BUTANESULTAM Usage And Synthesis

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 2162, 1987 DOI: 10.1021/jo00387a008

Synthesis

At room temperature, 4-chloro-1-butanesulfonamide (D5) (31 g, 200 mmol, 1.0 eq.) was dissolved in ethanol (500 mL), followed by the addition of sodium ethoxide (14.9 g, 220 mmol, 1.1 eq.). The reaction mixture was heated to reflux for 5 h. After completion of the reaction it was cooled to room temperature and concentrated under reduced pressure. The residual solid was fully extracted by adding dichloromethane to the residual solid and concentrated under reduced pressure after combining the organic phases. The resulting solid was ground with ether to afford tetrahydro-2H-1,2-thiazine 1,1-dioxide (D6) (18.7 g, 69% yield) as a light brown solid, which was used directly in the subsequent reaction without further purification.

References

[1] Patent: WO2004/111022, 2004, A1. Location in patent: Page/Page column 15
[2] Journal of Organic Chemistry, 1987, vol. 52, # 11, p. 2162 - 2166

1,4-BUTANESULTAM(37441-50-2)Related Product Information

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