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Sulfonamides and synergist

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Sulfa drugs developed rapidly in the 1930s, and there had been more than 20 species of the drugs for the clinical application. the status of sulfa drugs in chemotherapeutic agents declined after 1940s due to the occurrence of penicillin and other antibiotics. But sulfa drugs, whose  antibacterial activity will be enhanced when combined with trimethoprim the antibacterial synergist, are still commonly used antibacterial drugs for the advantages of broad antibacterial spectrum, enabled to be administered orally, more rapid absorption. Clarifying the mechanism of the action of sulfa drugs established anti-metabolic theory and opened up a new way for the development of new drugs. Currently there are sulfadiazine and sulfamethoxazole that are used most widely in clinical.

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Structure:
Chemical Name:
(S)-(-)-2-Methyl-2-propanesulfinamide
CAS:
343338-28-3
MF:
C4H11NOS
Structure:
Chemical Name:
3-(METHYLSULFONYLAMINO)PHENYLBORONIC ACID
CAS:
148355-75-3
MF:
C7H10BNO4S
Structure:
Chemical Name:
3-Aminobenzenesulfonamide
CAS:
98-18-0
MF:
C6H8N2O2S
Structure:
Chemical Name:
2-(Methanesulfonylamino)phenylboronic acid
CAS:
756520-78-2
MF:
C7H10BNO4S
Structure:
Chemical Name:
3-CARBOXYPROPANESULFONAMIDE
CAS:
175476-52-5
MF:
C4H9NO4S
Structure:
Chemical Name:
Trimethoprim
CAS:
738-70-5
MF:
C14H18N4O3
Structure:
Chemical Name:
(R)-(+)-2-Methyl-2-propanesulfinamide
CAS:
196929-78-9
MF:
C4H11NOS
Structure:
Chemical Name:
2-Bromobenzenesulphonyl chloride
CAS:
2905-25-1
MF:
C6H4BrClO2S
Structure:
Chemical Name:
4-(METHYLSULFONYLAMINO)PHENYLBORONIC ACID
CAS:
380430-57-9
MF:
C7H10BNO4S
Structure:
Chemical Name:
3-BROMOBENZENESULFONAMIDE
CAS:
89599-01-9
MF:
C6H6BrNO2S
Structure:
Chemical Name:
4-Bromobenzenesulfonamide
CAS:
701-34-8
MF:
C6H6BrNO2S
Structure:
Chemical Name:
Sulfadiazine
CAS:
68-35-9
MF:
C10H10N4O2S
Structure:
Chemical Name:
Silver sulfadiazine
CAS:
22199-08-2
MF:
C10H9AgN4O2S
Structure:
Chemical Name:
2-(N,N-Dimethylsulphamoyl)phenylboronic acid
CAS:
178432-25-2
MF:
C8H12BNO4S
Structure:
Chemical Name:
3-NITROBENZENESULFONAMIDE
CAS:
121-52-8
MF:
C6H6N2O4S
Structure:
Chemical Name:
Sulfanilamide
CAS:
63-74-1
MF:
C6H8N2O2S
Structure:
Chemical Name:
Sulfamethoxazole
CAS:
723-46-6
MF:
C10H11N3O3S
Structure:
Chemical Name:
3-Cyanophenylboronic acid
CAS:
150255-96-2
MF:
C7H6BNO2
Structure:
Chemical Name:
Sulfasalazine
CAS:
599-79-1
MF:
C18H14N4O5S
Structure:
Chemical Name:
Sulfamerazine
CAS:
127-79-7
MF:
C11H12N4O2S
Structure:
Chemical Name:
Sulfacetamide sodium
CAS:
127-56-0
MF:
C8H9N2NaO3S
Structure:
Chemical Name:
Sulfamethoxypyridazine
CAS:
80-35-3
MF:
C11H12N4O3S
Structure:
Chemical Name:
3-BROMO-N-TERT-BUTYLBENZENESULPHONAMIDE
CAS:
308283-47-8
MF:
C10H14BrNO2S
Chemical Name:
Sulfamonomethoxine sodium
MF:
C11H11N4NaO3S
Structure:
Chemical Name:
2-(Morpholinosulfonyl)phenylboronic acid
CAS:
957062-65-6
MF:
C10H14BNO5S
Structure:
Chemical Name:
2-METHANESULFONYLAMINOPHENYLBORONIC ACID, PINACOL ESTER
CAS:
380430-60-4
MF:
C13H20BNO4S
Structure:
Chemical Name:
Sulfamethazine sodium salt
CAS:
1981-58-4
MF:
C12H15N4NaO2S
Structure:
Chemical Name:
4-(Aminosulfonyl)phenylboronic acid
CAS:
613660-87-0
MF:
C6H8BNO4S
Structure:
Chemical Name:
Phthalylsulfathiazole
CAS:
85-73-4
MF:
C17H13N3O5S2
Structure:
Chemical Name:
3-AMINO-N,N-DIETHYL-BENZENESULFONAMIDE
CAS:
10372-41-5
MF:
C10H16N2O2S
Structure:
Chemical Name:
Mafenide hydrochloride
CAS:
138-37-4
MF:
C7H11ClN2O2S
Structure:
Chemical Name:
N-T-BUTYL 3-NITROBENZENESULFONAMIDE
CAS:
424818-25-7
MF:
C10H14N2O4S
Structure:
Chemical Name:
Succinylsulfathiazole
CAS:
116-43-8
MF:
C13H13N3O5S2
Structure:
Chemical Name:
(4-METHANESULFONYLAMINOMETHYL)PHENYL BORONIC ACID
CAS:
850568-38-6
MF:
C8H12BNO4S
Chemical Name:
Policresulen
CAS:
9011-02-3
MF:
(C15H16O8S2)n
Structure:
Chemical Name:
2-(PYRROLIDIN-1-YLSULPHONYL)BENZENEBORONIC ACID 97
CAS:
913835-83-3
MF:
C10H14BNO4S
Structure:
Chemical Name:
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
CAS:
78162-58-0
MF:
C5H9N3O2S
Structure:
Chemical Name:
P-CHLOROSULFONYLDIHYDROCINNAMIC ACID
CAS:
63545-54-0
MF:
C9H9ClO4S
Structure:
Chemical Name:
Sulfacetamide
CAS:
144-80-9
MF:
C8H10N2O3S
Structure:
Chemical Name:
SULFAMETHIZOLE
CAS:
144-82-1
MF:
C9H10N4O2S2
Structure:
Chemical Name:
3-(PIPERIDINOSULFONYL)ANILINE
CAS:
22184-99-2
MF:
C11H16N2O2S
Structure:
Chemical Name:
3-(1-PYRROLIDINYLSULFONYL)ANILINE
CAS:
91619-38-4
MF:
C10H14N2O2S
Structure:
Chemical Name:
Sulfadimethoxine sodium salt
CAS:
1037-50-9
MF:
C12H13N4NaO4S
Structure:
Chemical Name:
3-AMINO-N-CYCLOPROPYLBENZENESULFONAMIDE
CAS:
459434-39-0
MF:
C9H12N2O2S
Structure:
Chemical Name:
Sodium sulfadiazine
CAS:
547-32-0
MF:
C10H9N4NaO2S
Structure:
Chemical Name:
(3-AMINOSULPHONYL)BENZENEBORONIC ACID
CAS:
850568-74-0
MF:
C6H8BNO4S
Structure:
Chemical Name:
Sulfathiazole
CAS:
72-14-0
MF:
C9H9N3O2S2
Structure:
Chemical Name:
Sulfaguanidine
CAS:
57-67-0
MF:
C7H10N4O2S
Structure:
Chemical Name:
Sulfadimethoxine
CAS:
122-11-2
MF:
C12H14N4O4S
Structure:
Chemical Name:
3-(MORPHOLINOSULFONYL)ANILINE
CAS:
22184-97-0
MF:
C10H14N2O3S
Structure:
Chemical Name:
Sulfamethazine
CAS:
57-68-1
MF:
C12H14N4O2S
Structure:
Chemical Name:
N,N-DIMETHYL 4-IODO-1H-IMIDAZOLE-1-SULFONAMIDE
CAS:
135773-25-0
MF:
C5H8IN3O2S
Structure:
Chemical Name:
4-BROMO-N,N-DIMETHYLBENZENESULFONAMIDE
CAS:
707-60-8
MF:
C8H10BrNO2S
Structure:
Chemical Name:
4-(N,N-DIMETHYLSULPHONAMIDO)BENZENEBORONIC ACID
CAS:
486422-59-7
MF:
C8H12BNO4S
Structure:
Chemical Name:
3-BROMO-N-ETHYLBENZENESULPHONAMIDE
CAS:
871269-07-7
MF:
C8H10BrNO2S
Structure:
Chemical Name:
3-BROMO-N-METHYLBENZENESULPHONAMIDE
CAS:
153435-79-1
MF:
C7H8BrNO2S
Structure:
Chemical Name:
4-BROMO-N-ETHYLBENZENESULPHONAMIDE
CAS:
1984-25-4
MF:
C8H10BrNO2S
Structure:
Chemical Name:
1-(4-BROMOPHENYLSULFONYL)PYRROLIDINE
CAS:
136350-52-2
MF:
C10H12BrNO2S
Structure:
Chemical Name:
3-(Piperidin-1-ylsulphonyl)pyridine
CAS:
26103-49-1
MF:
C10H14N2O2S
Structure:
Chemical Name:
2-Bromo-N,N-dimethylbenzenesulphonamide
CAS:
65000-13-7
MF:
C8H10BrNO2S
Structure:
Chemical Name:
5-Bromo-N,N-diethylpyridine-3-sulphonamide
CAS:
62009-37-4
MF:
C9H13BrN2O2S
Structure:
Chemical Name:
2-Bromo-N-ethylbenzenesulphonamide
CAS:
169189-80-4
MF:
C8H10BrNO2S
Structure:
Chemical Name:
Sulfathiazole sodium
CAS:
144-74-1
MF:
C9H10N3NaO2S2
Structure:
Chemical Name:
N-BENZYL 5-BROMO-2-METHOXYBENZENESULFONAMIDE
CAS:
446308-82-3
MF:
C14H14BrNO3S
Structure:
Chemical Name:
2-([(4-BROMOPHENYL)SULFONYL]AMINO)ACETIC ACID
CAS:
13029-73-7
MF:
C8H8BrNO4S
Structure:
Chemical Name:
4-BROMO-N-METHYL-BENZENESULFONAMIDE
CAS:
703-12-8
MF:
C7H8BrNO2S
Structure:
Chemical Name:
3-BROMO-N-PYRROLIDIN-1-YLBENZENESULPHONAMIDE
CAS:
214210-14-7
MF:
C10H12BrNO2S
Structure:
Chemical Name:
3-(N-MORPHOLINYLSULPHONAMIDO)BENZENEBORONIC ACID
CAS:
871329-60-1
MF:
C10H14BNO5S
Structure:
Chemical Name:
(4-METHYLAMINOSULPHONYL)BENZENE BORONIC ACID
CAS:
226396-31-2
MF:
C7H10BNO4S
Structure:
Chemical Name:
SULFISOMIDINE
CAS:
515-64-0
MF:
C12H14N4O2S
Structure:
Chemical Name:
N-BENZYL 3-BROMO-4-METHYLBENZENESULFONAMIDE
CAS:
850429-67-3
MF:
C14H14BrNO2S
Structure:
Chemical Name:
4-METHOXY-3-(PIPERIDIN-1-YLSULPHONYL)BENZENEBORONIC ACID
CAS:
874219-18-8
MF:
C12H18BNO5S
Structure:
Chemical Name:
N,N-DIMETHYL 4,5-DIIODO-1H-IMIDAZOLE-1-SULFONAMIDE
CAS:
198127-92-3
MF:
C5H7I2N3O2S
Structure:
Chemical Name:
2-Bromo-N-(4-fluoroBenzyl)Benzenesulphonamide
CAS:
321705-40-2
MF:
C13H11BrFNO2S
Structure:
Chemical Name:
4-(N-BUTYLSULPHONAMIDO)BENZENEBORONIC ACID
CAS:
850589-32-1
MF:
C10H16BNO4S
Structure:
Chemical Name:
1-(4-BROMOPHENYLSULFONYL)PIPERIDINE
CAS:
834-66-2
MF:
C11H14BrNO2S
Structure:
Chemical Name:
3-(N,N-DIMETHYLSULPHONAMIDO)BENZENEBORONIC ACID
CAS:
871329-59-8
MF:
C8H12BNO4S
Structure:
Chemical Name:
4-Bromo-N-(4-methoxybenzyl)benzenesulfonamide
CAS:
329939-43-7
MF:
C14H14BrNO3S
Structure:
Chemical Name:
4-(N,N-DIETHYLSULPHONAMIDO)BENZENEBORONIC ACID
CAS:
850568-76-2
MF:
C10H16BNO4S
Structure:
Chemical Name:
Sulfabenzamide
CAS:
127-71-9
MF:
C13H12N2O3S
Structure:
Chemical Name:
4-(TERT-BUTYLAMINOSULPHONYL)BENZENEBORONIC ACID
CAS:
208516-15-8
MF:
C10H16BNO4S
Structure:
Chemical Name:
4-(AMINOMETHYL)BENZENESULFONAMIDE
CAS:
138-39-6
MF:
C7H10N2O2S
Structure:
Chemical Name:
N-(2-AMINOETHYL) 4-BROMOBENZENESULFONAMIDE
CAS:
90002-56-5
MF:
C8H11BrN2O2S
Structure:
Chemical Name:
1,4-BUTANESULTAM
CAS:
37441-50-2
MF:
C4H9NO2S
Structure:
Chemical Name:
Mafenide acetate
CAS:
13009-99-9
MF:
C9H14N2O4S
Structure:
Chemical Name:
4-BROMO-N-(3-CHLOROPROPYL)BENZENESULPHONAMIDE
CAS:
98768-71-9
MF:
C9H11BrClNO2S
Structure:
Chemical Name:
2-Bromo-N-(tert-butyl)benzenesulphonamide
CAS:
138733-50-3
MF:
C10H14BrNO2S
Structure:
Chemical Name:
4-Bromo-N-butylbenzamide
CAS:
78080-34-9
MF:
C11H14BrNO
Structure:
Chemical Name:
N-Isopropyl 2-bromobenzenesulfonamide
CAS:
951883-94-6
MF:
C9H12BrNO2S
Structure:
Chemical Name:
4-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE
CAS:
331950-30-2
MF:
C9H10BrNO2S
Structure:
Chemical Name:
2-METHYL-5-(N-MORPHOLINYLSULFONYL)PHENYLBORONIC ACID
CAS:
871329-74-7
MF:
C11H16BNO5S
Structure:
Chemical Name:
(3-METHANESULFONYLAMINOMETHYL)BENZENEBORONIC ACID
CAS:
850568-39-7
MF:
C8H12BNO4S
Structure:
Chemical Name:
3-AMINO-N-(TERT-BUTYL)BENZENESULFONAMIDE
CAS:
608523-94-0
MF:
C10H16N2O2S
Structure:
Chemical Name:
Sulfamonomethoxine
CAS:
1220-83-3
MF:
C11H12N4O3S
Structure:
Chemical Name:
2-(N,N-diethylsulfamoyl)phenylboronic acid
CAS:
957061-16-4
MF:
C10H16BNO4S
Structure:
Chemical Name:
3-(PYRROLIDIN-1-YLSULFONYL)PHENYLBORONIC ACID
CAS:
871329-61-2
MF:
C10H14BNO4S
Structure:
Chemical Name:
4-(N-ISOPROPYLSULFAMOYL)PHENYLBORONIC ACID
CAS:
850589-31-0
MF:
C9H14BNO4S
Structure:
Chemical Name:
3-AMINO-N-METHYLBENZENESULFONAMIDE
CAS:
459434-40-3
MF:
C7H10N2O2S
Structure:
Chemical Name:
4-(N-CYCLOPROPYLSULPHONAMIDO)BENZENEBORONIC ACID
CAS:
871329-67-8
MF:
C9H12BNO4S
Structure:
Chemical Name:
3-(N-CYCLOPROPYLSULPHAMOYL)BENZENEBORONIC ACID 98
CAS:
913835-28-6
MF:
C9H12BNO4S