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Sulfonamides and synergist

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Sulfa drugs developed rapidly in the 1930s, and there had been more than 20 species of the drugs for the clinical application. the status of sulfa drugs in chemotherapeutic agents declined after 1940s due to the occurrence of penicillin and other antibiotics. But sulfa drugs, whose  antibacterial activity will be enhanced when combined with trimethoprim the antibacterial synergist, are still commonly used antibacterial drugs for the advantages of broad antibacterial spectrum, enabled to be administered orally, more rapid absorption. Clarifying the mechanism of the action of sulfa drugs established anti-metabolic theory and opened up a new way for the development of new drugs. Currently there are sulfadiazine and sulfamethoxazole that are used most widely in clinical.

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Structure:
Chemical Name:
1-(3-NITROPHENYLSULFONYL)PYRROLIDINE
CAS:
91619-30-6
MF:
C10H12N2O4S
Structure:
Chemical Name:
2-Bromo-N-(3-methoxypropyl)benzenesulphonamide
CAS:
848906-56-9
MF:
C10H14BrNO3S
Structure:
Chemical Name:
N-CYCLOHEXYL 3-NITROBENZENESULFONAMIDE
CAS:
93125-79-2
MF:
C12H16N2O4S
Structure:
Chemical Name:
3-N-CYCLOHEXYLSULFAMOYLPHENYLBORONIC ACID
CAS:
871329-79-2
MF:
C12H18BNO4S
Structure:
Chemical Name:
3-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE 98
CAS:
876694-43-8
MF:
C9H10BrNO2S
Structure:
Chemical Name:
4-(3-BROMOPHENYLSULFONYL)MORPHOLINE
CAS:
871269-13-5
MF:
C10H12BrNO3S
Structure:
Chemical Name:
5-BROMO-N-T-BUTYL-2-METHOXYBENZENESULFONAMIDE
CAS:
871269-15-7
MF:
C11H16BrNO3S
Structure:
Chemical Name:
N-tert-butylbenzenesulfonamide
CAS:
2512-24-5
MF:
C10H15NO2S
Structure:
Chemical Name:
1-(2-Bromophenylsulfonyl)pyrrolidine
CAS:
929000-58-8
MF:
C10H12BrNO2S
Structure:
Chemical Name:
2-Bromo-N-(2,3-dimethylphenyl)benzenesulfonamide
CAS:
941294-37-7
MF:
C14H14BrNO2S
Structure:
Chemical Name:
N-Methyl 3-bromo-4-methylbenzenesulfonamide
CAS:
941294-51-5
MF:
C8H10BrNO2S
Structure:
Chemical Name:
sulfamethazine-n4-acetyl
CAS:
100-90-3
MF:
C14H16N4O3S
Structure:
Chemical Name:
SULFATHIAZOLE-D4
CAS:
1020719-89-4
MF:
C9H5D4N3O2S2
Structure:
Chemical Name:
N,N-DIMETHYL 3-BROMO-4-METHYLBENZENESULFONAMIDE
CAS:
850429-72-0
MF:
C9H12BrNO2S
Structure:
Chemical Name:
N-ISOPROPYL 3-BROMO-4-METHYLBENZENESULFONAMIDE
CAS:
850429-66-2
MF:
C10H14BrNO2S
Structure:
Chemical Name:
SULFISOXAZOLE ACETYL (200 MG)
CAS:
80-74-0
MF:
C13H15N3O4S
Chemical Name:
sulfamethoxazole,SMZ
Structure:
Chemical Name:
3-Bromo-N-(3-chloropropyl)benzenesulfonamide
CAS:
929000-46-4
MF:
C9H11BrClNO2S
Structure:
Chemical Name:
N-(2-BOC-AMINOETHYL)-4-BROMOBENZENESULFONAMIDE
CAS:
310480-85-4
MF:
C13H19BrN2O4S
Structure:
Chemical Name:
4-(4-BROMOPHENYLSULFONYL)THIOMORPHOLINE
CAS:
223555-81-5
MF:
C10H12BrNO2S2
Structure:
Chemical Name:
MAFENIDE ACETATE
CAS:
7761-27-5
MF:
C9H14N2O4S
Structure:
Chemical Name:
N-ETHYL 3-BROMO-4-METHYLBENZENESULFONAMIDE
CAS:
850429-65-1
MF:
C9H12BrNO2S
Structure:
Chemical Name:
N-(2,4-Difluorophenyl) 2-bromobenzenesulfonamide
CAS:
941294-30-0
MF:
C12H8BrF2NO2S
Structure:
Chemical Name:
3-N,N-dimethylsulfamoylpyridine
CAS:
4810-41-7
MF:
C7H10N2O2S
Structure:
Chemical Name:
1-(3-BROMO-4-METHYLPHENYLSULFONYL)PYRROLIDINE
CAS:
850429-75-3
MF:
C11H14BrNO2S
Structure:
Chemical Name:
p-[(2,4-diaminophenyl)azo]benzenesulphonamide
CAS:
103-12-8
MF:
C12H13N5O2S
Structure:
Chemical Name:
3-(N-ETHYLSULFAMOYL)PHENYLBORONIC ACID
CAS:
871329-76-9
MF:
C8H12BNO4S
Structure:
Chemical Name:
N,N-DIETHYL 3-BROMO-4-METHYLBENZENESULFONAMIDE
CAS:
850429-71-9
MF:
C11H16BrNO2S
Structure:
Chemical Name:
SULFADIAZINE-D4
CAS:
1020719-78-1
MF:
C10H6D4N4O2S
Structure:
Chemical Name:
PHTHALYLSULFACETAMIDE
CAS:
131-69-1
MF:
C16H14N2O6S
Structure:
Chemical Name:
Sulpamethoxydiazine sodium
MF:
C5H6N2NaO4S
Structure:
Chemical Name:
Sulfacytine
CAS:
1401-49-6
MF:
C12H14N4O3S
Structure:
Chemical Name:
SULFAPHENAZOLE
CAS:
526-08-9
MF:
C15H14N4O2S
Structure:
Chemical Name:
SULFAMETHOXAZOLE-D4
MF:
C10H7D4N3O3S
Structure:
Chemical Name:
N-CYCLOHEXYL 3-BROMOBENZENESULFONAMIDE
CAS:
871269-10-2
MF:
C12H16BrNO2S
Structure:
Chemical Name:
N,N-DIETHYL 3-NITROBENZENESULFONAMIDE
CAS:
6335-26-8
MF:
C10H14N2O4S
Structure:
Chemical Name:
3-(P-TolylcarbaMoyl)phenylboronic acid
CAS:
1072946-03-2
MF:
C14H14BNO3
Structure:
Chemical Name:
N-BUTYL 3-BROMO-4-METHYLBENZENESULFONAMIDE
CAS:
850429-68-4
MF:
C11H16BrNO2S
Structure:
Chemical Name:
N-CYCLOHEXYL 3-BROMO-4-METHYLBENZENESULFONAMIDE
CAS:
850429-69-5
MF:
C13H18BrNO2S
Structure:
Chemical Name:
Sulfamerazine sodium
CAS:
127-58-2
MF:
C11H13N4NaO2S
Structure:
Chemical Name:
N-T-BUTYL 3-BROMO-4-METHYLBENZENESULFONAMIDE
CAS:
850429-70-8
MF:
C11H16BrNO2S