adenosine N1-oxide
adenosine N1-oxide Basic information
- Product Name:
- adenosine N1-oxide
- Synonyms:
-
- 6-AMINO-9-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]PURIN-7-IUM-7-OLATE
- adenosine N1-oxide
- adenosine N(sup 1)-oxide
- 1-Oxylatoadenosine-1-ium
- Adenosine 1-oxide
- 1-Oxoadenosine
- Adenosine N1-Oxide, ANO
- ANO
- CAS:
- 146-92-9
- MF:
- C10H13N5O5
- MW:
- 283.24
- EINECS:
- 205-683-0
- Mol File:
- 146-92-9.mol
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adenosine N1-oxide Chemical Properties
- Melting point:
- 155 °C
- Boiling point:
- 777.4±70.0 °C(Predicted)
- Density
- 2.15±0.1 g/cm3(Predicted)
- pka
- 13.03±0.70(Predicted)
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adenosine N1-oxide Usage And Synthesis
Uses
Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide promotes osteogenic and adipocyte differentiation[1][2].
in vivo
Adenosine N1-oxide (oral administration, 135 mg/kg for three times) reduces the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice[1].
| Animal Model: | LPS-induced endotoxin shock in BALB/c mice[1] |
| Dosage: | 135 mg/kg for three times |
| Administration: | Oral administration |
| Result: | Reduced the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice. |
References
[1] Kohno K, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015;12(1):2. Published 2015 Jan 20. DOI:10.1186/s12950-014-0045-0
[2] Ohashi E, et al. Adenosine N1-Oxide Exerts Anti-inflammatory Effects through the PI3K/Akt/GSK-3β Signaling Pathway and Promotes Osteogenic and Adipocyte Differentiation. Biol Pharm Bull. 2019;42(6):968-976. DOI:10.1248/bpb.b18-00988
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