(±)-alpha-[[isopropylamino]methyl]-4-nitrobenzyl alcohol monohydrochloride
(±)-alpha-[[isopropylamino]methyl]-4-nitrobenzyl alcohol monohydrochloride Basic information
- Product Name:
- (±)-alpha-[[isopropylamino]methyl]-4-nitrobenzyl alcohol monohydrochloride
- Synonyms:
-
- (±)-alpha-[[isopropylamino]methyl]-4-nitrobenzyl alcohol monohydrochloride
- 1-(4-Nitrophenyl)-1-hydroxy-2-isopropylaminoethane hydrochloride
- Benzenemethanol, α-[[(1-methylethyl)amino]methyl]-4-nitro-, monohydrochloride (9CI)
- Nifenalol (hydrochloride)
- ()-alpha-[[isopropylamino]methyl]-4-nitrobenzylalcoholmonohydrochloride
- Nifenalol monohydrochloride
- INPEA
- Benzenemethanol, α-[[(1-methylethyl)amino]methyl]-4-nitro-, monohydrochloride
- CAS:
- 5704-60-9
- MF:
- C11H16N2O3.ClH
- MW:
- 260.72
- EINECS:
- 227-194-1
- Mol File:
- 5704-60-9.mol
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(±)-alpha-[[isopropylamino]methyl]-4-nitrobenzyl alcohol monohydrochloride Chemical Properties
- Melting point:
- 181°
- storage temp.
- -20°C
- solubility
- DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- White to off-white
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(±)-alpha-[[isopropylamino]methyl]-4-nitrobenzyl alcohol monohydrochloride Usage And Synthesis
Uses
Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure[1].
IC 50
β-adrenoceptor
References
[1] Lemmens-Gruber R, et al. Arrhythmogenic effect of beta-adrenoceptor-blocking drugs in Purkinje fibres of guinea-pig hearts. Arch Int Pharmacodyn Ther. 1996 Jan-Feb;331(1):46-58. PMID:8896710
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