Basic information Safety Supplier Related

chlormerodrin

Basic information Safety Supplier Related

chlormerodrin Basic information

Product Name:
chlormerodrin
Synonyms:
  • MERCURY,CHLORO(2-METHOXY-3-UREIDOPROPYL)-
  • Diurone【diuretic】
  • Katonil
  • Mercoral
  • Merilid
  • Oricur
  • Percapyl
  • [3-(Chloromercuri)-2-methoxypropyl]urea
CAS:
62-37-3
MF:
C5H11ClHgN2O2
MW:
367.197
EINECS:
200-530-4
Mol File:
62-37-3.mol
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chlormerodrin Chemical Properties

Melting point:
152-153°
Boiling point:
142°C
form 
solid
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Safety Information

Toxicity
LD50 orally in rats: ~82 mg/kg (Goldenthal)
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chlormerodrin Usage And Synthesis

Originator

Neohydrin,Lakeside,US,1952

Uses

Chlormerodrin is a sulfhydryl blocking agent; using NK cells, particularly CAR-modified NK cells, for producing induced cellular vesicles (ICVs) loaded with chemotherapeutic agent(s) for cancer therapy.

Definition

ChEBI: Chlormerodrin is urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. It has a role as a diuretic and a diagnostic agent. It is an organomercury compound and a member of ureas.

Manufacturing Process

To a refluxing solution of 100 g of allyl urea and 600 ml of absolute methanol there was added with stirring a suspension of 319 g of mercuric acetate and 600 ml of absolute methanol and 60 ml of glacial acetate acid; complete solution resulted. After 6 hours of refluxing, the solution was cooled and clarified by filtration. To this solution there were added 50 g of sodium chloride and 240 ml of water. After a short time a heavy white precipitate settled out. This precipitate, which was 3-chloromercuri-2-methoxypropylurea, was filtered, washed and dried.

brand name

Mercloran (Parke-Davis); Neohydrin (Marion Merrell Dow).

Therapeutic Function

Diuretic

chlormerodrinSupplier

SPIRO PHARMA
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eric_feng1954@126.com
Hubei Nordina Biotechnology Co., Ltd.
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19371278702
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nuodinashengwu@163.com
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
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17691182729 18161915376
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1046@dideu.com
Hubei huizepu Pharmaceutical Technology Co., Ltd
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023-19371278 19371278702
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n13164103386@163.com