Product Identification

Product Name

Phenylhydrazine hydrochloride

Synonyms

Hydrazine, phenyl-, monohydrochloride
Phenylhydrazinium chloride

CAS

59-88-1

Formula

C6H9ClN2

Molecular Weight

144.61000000000001

EINECS

200-444-7

RTECS

MV9000000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector

Merck

12,7447

Beilstein/Gmelin

3594958

Beilstein Reference

3-15-00-00067

EC Index Number

612-023-00-9

EC Class

Carcinogenic Category 2; Mutagenic Category 3; Toxic; Irritant; Sensitising; Dangerous for the Environment

Physical and Chemical Properties

Appearance

White, odorless powder.

Solubility in water

50 g/L

Melting Point

243 - 246

Usage

Used in preparation of indoles which are intermediates in the synthesis of various dyes and pharmaceuticals.

First Aid Measures

Ingestion

Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store protected from light. Store under an inert atmosphere.

Handling

Wash thoroughly after handling. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Store protected from light. Handle under an inert atmosphere. Store protected from air. Use only in a chemical fume hood.

Hazards Identification

Inhalation

Harmful if inhaled. Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Acute exposure to low concentrations of hydrazines may cause and produce bronchial mucous destruction, pulmonary edema, cyanosis and possible death.

Skin

Causes skin irritation. Harmful if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May cause eczematous dermatitis with swelling and vesiculation.

Eyes

Causes eye irritation.

Ingestion

Harmful if swallowed. May cause liver and kidney damage. Causes gastrointestinal tract irritation. May cause systemic effects by ingestion: blood hemolysis with or without anemia, methemoglobinemia-carboxyhemoglobinemia, and pulmonary changes. May cause central nervous system stimulation.

Hazards

Toxic and irritating hydrogen chloride and oxides of nitrogen may be produced in fire. May be corrosive to metals.

EC Risk Phrase

R 45 23/24/25 36/38 43 48/23/24/25 50 68

EC Safety Phrase

S 53 45 61

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Prolonged or repeated skin contact may cause dermatitis. Prolonged or repeated eye contact may cause conjunctivitis. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. May cause fetal effects. May cause cancer according to animal studies. Laboratory experiments have resulted in mutagenic effects. Chronic inhalation may cause liver damage.

Poison Class

3

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Extinguishing media: Use extinguishing media most appropriate for the surrounding fire. In case of fire, use carbon dioxide, dry chemical, or water fog.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Place under an inert atmosphere.

Stability and Reactivity

Disposal Code

9

Incompatibilities

Air, strong oxidizing agents, lead dioxide, common metals (expect aluminum), bases.

Stability

Stable under normal temperatures and pressures. May violently decompose at temperatures above 190 C.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III

HS Code

2928 00 90