Product Identification

Product Name

Dapsonum

Synonyms

2-Octanol, (R)-
4-((4-Aminophenyl)sulfonyl)phenylamine
4,4'-Sulfonyldianiline
4,4'-Sulphonyldianiline
4-Aminophenyl sulfone
Dapsone
Sumicure S

CAS

5978-70-1

CAS

80-08-0

Formula

C12H12N2O2S

Formula

C8H18O

Molecular Weight

248.31

Molecular Weight

130.22999999999999

EINECS

201-248-4

EINECS

227-777-0

RTECS

BY8925000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,6850

Merck

13,2847

Beilstein/Gmelin

1719324

Beilstein/Gmelin

788055

Beilstein Reference

3-01-00-01721

Beilstein Reference

4-13-00-01306

EC Index Number

612-084-00-1

EC Class

Harmful

EC Class

irritant

Physical and Chemical Properties

Appearance

Clear, colorless liquid.

Appearance

Odorless white or creamy white crystalline powder. Slightly bitter taste.

Solubility in water

Slightly soluble

Solubility in water

Insoluble

Melting Point

172 - 175

Boiling Point

175

Boiling Point

438

Density

0.8201 g/cm3 (20 C)

Density

1.39 g/cm3

pKa/pKb

13.0 (pKb)

Partition Coefficient

.89

Usage

Therap cat: antibacterial (leprostatic), in treatment of dermititis herpetiformis. Therap cat (vet): antibacterial, coccidostat.

Vapor Density

8.3

Refractive Index

1.4256 (20 C)

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Get medical aid immediately.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Inhalation

Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation.

Inhalation

Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear.

Skin

Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Skin

Causes skin irritation.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Eyes

Causes eye irritation. May cause eye burns. Vapors cause eye irritation.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Ingestion

May cause irritation of the digestive tract.

Ingestion

See inhalation.

Inhalation

Symptoms of exposure to this compound include somnolence, retinal changes, cyanosis, jaundice, changes in tubules and other kidney changes, hemolysis with or without anemia, joint effects, hepatitis, dermatitis and peripheral neuritis. Other symptoms include peripheral motor neuropathy, retinal damage, optic atrophy and, in large doses, intravascular hemolysis, methemoglobinemia, renal failure, hemorrhages and exudates in fundi, localized capillary non-perfusion by angiography, and permanent poor vision.

Skin

See inhalation.

Eyes

See inhalation

Hazards

Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers.

EC Risk Phrase

R 22

EC Risk Phrase

R 36/37/38

EC Safety Phrase

S 22

EC Safety Phrase

S 26 36

UN (DOT)

1986

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Respirators

Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).

Poison Class

3

Poison Class

4 (Substances and products that must be considered harmful)

Fire Fighting Measures

Flash Point

60

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustible Liquid. Can form explosive mixtures at temperatures above the flashpoint. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Fire Potential

This chemical is probably combustible.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.

Small spills/leaks

If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Incompatibilities

Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides Incompatible with strong oxidizing agents Incompatible with epoxy resins under uncontrolled conditions.

Stability

No data.

Incompatibilities

Oxidizing agents, acids, acid chlorides, acid anhydrides..

Stability

Stable under normal temperatures and pressures.

Disposal Code

1

Decomposition

Carbon monoxide, carbon dioxide.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

1986

Hazard Class

3

Packing Group

I; II; III

HS Code

2905 16 20

HS Code

2930 90 70