Product Identification

Product Name

Thiamine chloride

Synonyms

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride
Aneurine
Thiamin
Thiamine chloride
Thiazolium, 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride

CAS

59-43-8

Formula

C12H17N4OS.Cl

Molecular Weight

300.81

EINECS

200-425-3

RTECS

XI6550000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,9430

Beilstein/Gmelin

3581326

Beilstein Reference

4-27-00-01764

Physical and Chemical Properties

Appearance

Off-white powder with a characteristic odor.

Solubility in water

Slightly soluble.

Melting Point

128 - 129

Boiling Point

122-128 (0.03 torr):

Vapor Pressure

Negliglible.

Density

1.43 g/cm3

Usage

Prevention and treatment of vitamin b1 deficiency.

Vapor Density

10.4

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.

Hazards Identification

Ingestion

Nausea, vomiting, abdominal pain, and diarrhea are common, especially following ingestion of multiple vitamins with iron (see iron management).

Inhalation

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.

Skin

May cause skin irritation. May cause dermatitis.

Eyes

May cause irritation.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

100

Autoignition

365

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately. Use protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.