Product Identification

Product Name

Salicylazosulfapyridine

Synonyms

2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid
5-[p-(2-Pyridylsulfamyl)phenylazo]salicylic acid
Azopyrine
Benzosulfa
Reupirin
Salicylazosulfapyridine

CAS

599-79-1

Formula

C18H14N4O5S

Molecular Weight

398.4

EINECS

209-974-3

RTECS

VO6250000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,9112

Beilstein/Gmelin

356241

Beilstein Reference

5-22-08-00433

Physical and Chemical Properties

Appearance

Odorless yellow or brownish-yellow to orange powder. Tasteless.

Solubility in water

Slightly soluble

Melting Point

240

Density

1.497 g/cm3 (25 C)

pKa/pKb

2.88 (pKa)

Partition Coefficient

-.7

Usage

Medication.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Ingestion

See inhalation.

Inhalation

Symptoms of exposure to this compound include hemolytic Heinz-body anemia, transient reticulocytosis, cyanosis, leukopenia, agranulocytosis, neurotoxicity and pancreatitis.

Skin

See inhalation.

Eyes

See inhalation

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Fire Fighting Measures

Fire Fighting

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Stability

No data.