Product Identification

Product Name

Sirolimus

Synonyms

(-)-Rapamycin
Antibiotic AY-22989
AY-22989
NSC-226080
SILA-9268A
Sirolimus

CAS

53123-88-9

Formula

C51H79NO13

Molecular Weight

914.19

RTECS

VE6250000

Merck

12,8288

Beilstein/Gmelin

5848501

Beilstein Reference

6-27

Physical and Chemical Properties

Appearance

White to off-white powder.

Solubility in water

Insoluble

Melting Point

183 - 184

Density

1.18 g/cm3

pKa/pKb

10.40 (pKa)

Partition Coefficient

3.58

Usage

Tool for immunochemistry.

Handling and Storage

Storage

Store solid and solutions at -20 ºC

Hazards Identification

Inhalation

If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration

Skin

Flush with copious amounts of water; remove contaminated clothing and shoes; call a physician

Eyes

Check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician

Ingestion

Wash out mouth with copious amounts of water; call a physician

Exposure Controls/Personal Protection

Personal Protection

Protective clothing, heavy rubber gloves, chemical safety goggles.

Respirators

NIOSH/MSHA-approved respirator.

Exposure Effects

Potent immunosuppresent; may cause irritation to eyes, skin, mucous membranes.

Fire Fighting Measures

Fire Fighting

Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam. Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol.

Stability and Reactivity

Stability

Stable if stored as directed.

Incompatibilities

Strong oxidizing agents.