Product Identification

Product Name

16a(R),17-(Butylidenebis(oxy))-11b,21-dihydroxypregna-1,4-diene-3,20-dione

Synonyms

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 16,17-[butylidenebis(oxy)]-11,21-dihydroxy-, (11b,16a)-

CAS

51333-22-3

Formula

C25H34O6

Molecular Weight

430.54

EINECS

257-139-7

RTECS

TU3723000

RTECS Class

Drug; Reproductive Effector; Human Data; Hormone

Merck

12,1490

Beilstein/Gmelin

3633996

Beilstein Reference

5-19-06-00575

Physical and Chemical Properties

Solubility in water

Insoluble

Vapor Pressure

7E-17 (25 C)

pKa/pKb

12.85 (pKa)

Heat Of Vaporization

102.4 kJ/mol

Usage

An anti-inflammatory agent in the treatment of asthma, rhinitis, and inflammatory bowel disease.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.

Exposure Effects

Harmful. Limited evidence of a carcinogenic effect. Possible teratogen.

Fire Fighting Measures

Flash Point

202

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Hazards Identification

EC Risk Phrase

40

EC Safety Phrase

22 36