Product Identification

Product Name

Daunomycin

Synonyms

5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
Cerubidine
Daunoblastin
Daunomycin chlorohydrate
Daunomycin, hydrochloride
Daunorubicin hydrochloride

CAS

20830-81-3

Formula

C27H30ClNO10

Molecular Weight

564.03

EINECS

245-723-4

RTECS

HB7878000

RTECS Class

Drug; Mutagen

Beilstein/Gmelin

4229221

Physical and Chemical Properties

Appearance

Orange-red powder.

Melting Point

189

Partition Coefficient

9.94

Usage

A pharmacological active drug used for the treatment of acute leukemia.

First Aid Measures

Ingestion

If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Protect from light in tightly sealed container.

Handling

Use in Class II biological safety cabinet.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).

Exposure Effects

No effects have been reported.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Wet spil - clean with a 5% bleach solution until colorless liqud results. Absorb on inert material and transfer to plastic bags for disposal. Wear protective equipment.

Stability and Reactivity

Stability

Stable.

Incompatibilities

Strong oxidizing agents.

Decomposition

NIOSH approved respirator during operations producing aerosols.