Product Identification

Product Name

21-Desoxybetamethasone

Synonyms

9-Fluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione

CAS

382-67-2

Formula

C22H29FO4

Molecular Weight

376.47

EINECS

206-845-3

RTECS

TU3834000

RTECS Class

Reproductive Effector; Hormone

Merck

12,2975

Beilstein/Gmelin

2228097

Beilstein Reference

6-08

Physical and Chemical Properties

Solubility in water

Insoluble

Melting Point

217

Vapor Pressure

2E-13 (25 C)

pKa/pKb

12.80 (pKa)

Heat Of Vaporization

92.9 kJ/mol

Usage

A topical steroid used to treat inflammation caused by a number of conditions such as allergic reactions, eczema, and psoriasis.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Hazards Identification

Inhalation

Material is irritating to mucous membranes and upper respiratory tract.

EC Risk Phrase

20/21/22 36/37/38 40 43

EC Safety Phrase

22 26 36

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Harmful. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect. May cause sensitization by skin contact. Target organ(s): Pituitary. Poss

Fire Fighting Measures

Flash Point

276

Fire Fighting

Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Decomposition

Carbon monoxide, Carbon dioxide, Hydrogen fluoride.